Epidemiological studies provided the first evidence suggesting a connection between the
circadian clock and human health. Mutant mice convincingly demonstrate the principle that …

The interest in the systematic study of the circadian typology (CT) is relatively recent and has
developed rapidly in the two last decades. All the existing data suggest that this individual …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Major depressive disorder is one of the most common psychiatric illnesses in the United
States, with an estimated lifetime prevalence of up to 17%. 1 Affected individuals are at high …

Sleep disturbance is increasingly recognized as an important, but understudied, mechanism
in the complex and multi-factorial causation of the symptoms and functional disability …

There are no specific structural neuropathological hallmarks found in the brain of mood
disorders. Instead, there are molecular, functional and structural alterations reported in many …

Objective The aim of this article is to review progress in understanding the mechanisms that
underlie circadian and sleep rhythms, and their role in the pathogenesis and treatment of …

Bright light therapy for seasonal affective disorder (SAD) has been investigated and applied
for over 20 years. Physicians and clinicians are increasingly confident that bright light …

Synchronizing circadian (24 h) rhythms in physiology and behavior with the environmental
light-dark cycle is critical for maintaining optimal health. Dysregulation of the circadian …

For many years, researchers have suggested that abnormalities in circadian rhythms may
underlie the development of mood disorders such as bipolar disorder (BPD), major …