Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
The circadian immune system
C Wang, LK Lutes, C Barnoud, C Scheiermann - Science immunology, 2022 - science.org
The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …
the first to identify immune responses to be under a circadian control. Only in the last …
Interplay between circadian clock and cancer: new frontiers for cancer treatment
Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …
Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
T Bae, SP Hallis, MK Kwak - Experimental & Molecular Medicine, 2024 - nature.com
Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy
production. Cells adapt to varying oxygen levels through intricate response systems …
production. Cells adapt to varying oxygen levels through intricate response systems …
Reactive oxygen species and NRF2 signaling, friends or foes in cancer?
R Wang, L Liang, M Matsumoto, K Iwata, A Umemura… - Biomolecules, 2023 - mdpi.com
The imbalance between reactive oxygen species (ROS) production and clearance causes
oxidative stress and ROS, which play a central role in regulating cell and tissue physiology …
oxidative stress and ROS, which play a central role in regulating cell and tissue physiology …
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …
in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology …
Neuroinflammation, sleep, and circadian rhythms
MR Zielinski, AJ Gibbons - Frontiers in cellular and infection …, 2022 - frontiersin.org
Molecules involved in innate immunity affect sleep and circadian oscillators and vice versa.
Sleep-inducing inflammatory molecules are activated by increased waking activity and …
Sleep-inducing inflammatory molecules are activated by increased waking activity and …
[HTML][HTML] AMPK and NRF2: Interactive players in the same team for cellular homeostasis?
E Petsouki, SNS Cabrera, EH Heiss - Free Radical Biology and Medicine, 2022 - Elsevier
NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …
Circadian clocks guide dendritic cells into skin lymphatics
SJ Holtkamp, LM Ince, C Barnoud, MT Schmitt… - Nature …, 2021 - nature.com
Migration of leukocytes from the skin to lymph nodes (LNs) via afferent lymphatic vessels
(LVs) is pivotal for adaptive immune responses,. Circadian rhythms have emerged as …
(LVs) is pivotal for adaptive immune responses,. Circadian rhythms have emerged as …