Various strategies have been applied to replace the loss of cardiomyocytes in order to
restore reduced cardiac function and prevent the progression of heart disease. Intensive …

Candidate cardiomyocyte (CM) mitogens such as those affecting the extracellular signal–
regulated kinase (ERK) signaling pathway represent potential targets for functional heart …

Heart development is controlled by a relatively conserved network of transcriptional and
chromatin regulators; how the human heart has evolved species-specific features to …

Congenital heart defects (CHDs) are the most common birth defect in human with an
incidence of almost 1% of all live births. Most cases have a multifactorial origin with both …

Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for
protein sequence and expression conservation. In this study, we investigated its effect on the …

Mitogens capable of promoting cardiomyocyte proliferation represent important targets for
functional heart regeneration following myocardial infarction. We previously described an …

Acute myocardial infarction is a life-threatening condition that occurs as a result of reduced
blood flow in the cardiac muscle, eventually leading to tissue damage. In infarcted areas …

Congenital heart defects (CHD) are the most common birth defect, occurring in
approximately 1% of all births and continue to be a significant cause of infant morbidity and …

Introduction: Congenital heart defect (CHD) is the most common type of birth defect. Many
investigations have been conducted on CHD prevalence. However, a summary of …