Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

Anterograde intraflagellar transport (IFT) trains are essential for cilia assembly and
maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and …

Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …

During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

Chemical synapses between axons and dendrites mediate neuronal intercellular
communication. Here, we describe a synapse between axons and primary cilia: the axo …

Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …