Generation of circadian rhythms in the suprachiasmatic nucleus

MH Hastings, ES Maywood… - Nature Reviews …, 2018 - nature.com
The suprachiasmatic nucleus (SCN) of the hypothalamus is remarkable. Despite numbering
only about 10,000 neurons on each side of the third ventricle, the SCN is our principal …

Regulating the suprachiasmatic nucleus (SCN) circadian clockwork: interplay between cell-autonomous and circuit-level mechanisms

ED Herzog, T Hermanstyne… - Cold Spring …, 2017 - cshperspectives.cshlp.org
The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing
daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous …

[HTML][HTML] Light input pathways to the circadian clock of insects with an emphasis on the fruit fly Drosophila melanogaster

C Helfrich-Förster - Journal of Comparative Physiology A, 2020 - Springer
Light is the most important Zeitgeber for entraining animal activity rhythms to the 24-h day. In
all animals, the eyes are the main visual organs that are not only responsible for motion and …

[HTML][HTML] The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit

AP Patton, MD Edwards, NJ Smyllie, R Hamnett… - Nature …, 2020 - nature.com
The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian
timekeeper, co-ordinating organism-wide daily and seasonal rhythms. To achieve this, cell …

Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects

D Nesan, KM Feighan, MC Antle, DM Kurrasch - Science Advances, 2021 - science.org
Critical physiological processes such as sleep and stress that underscore health are
regulated by an intimate interplay between the endocrine and nervous systems. Here, we …

The suprachiasmatic nucleus at 50: looking back, then looking forward

D Ono, DR Weaver, MH Hastings… - Journal of biological …, 2024 - journals.sagepub.com
It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the
central circadian clock and 25 years since the last overview of developments in the field was …

[HTML][HTML] Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks

JL Bedont, S Blackshaw - Frontiers in systems neuroscience, 2015 - frontiersin.org
The circadian system constrains an organism's palette of behaviors to portions of the solar
day appropriate to its ecological niche. The central light-entrained clock in the …

Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling

MD Edwards, M Brancaccio… - Proceedings of the …, 2016 - National Acad Sciences
Circadian rhythms in mammals are coordinated by the suprachiasmatic nucleus (SCN). SCN
neurons define circadian time using transcriptional/posttranslational feedback loops (TTFL) …

[HTML][HTML] Timed daily exercise remodels circadian rhythms in mice

ATL Hughes, RE Samuels, B Baño-Otálora… - Communications …, 2021 - nature.com
Regular exercise is important for physical and mental health. An underexplored and
intriguing property of exercise is its actions on the body's 24 h or circadian rhythms …

Arginine–vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo

A Stowie, Z Qiao, DDC Buonfiglio… - Proceedings of the …, 2023 - National Acad Sciences
The suprachiasmatic nucleus (SCN) is composed of functionally distinct subpopulations of
GABAergic neurons which form a neural network responsible for synchronizing most …