Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated
ion channels and function as such in the central and peripheral nervous systems. Recently …

GABAB receptors (GABABRs) are G protein-coupled receptors for GABA, the main inhibitory
neurotransmitter in the CNS. In the past 5 years, notable advances have been made in our …

Spinal cord injury induces maladaptive synaptic transmission in the somatosensory system
that results in chronic central neuropathic pain. Recent literature suggests that glial-neuronal …

This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …

Abstract α-Conotoxins are disulfide-rich and well-structured peptides, most of which can
block nicotinic acetylcholine receptors (nAChRs) with exquisite selectivity and potency …

Neuropathic pain is a complex and debilitating syndrome for which there are few effective
pharmacological treatments. Opioid‐based medications are initially effective for acute pain …

Spinal dorsal horn GABAA receptors are found both postsynaptically on central neurons and
presynaptically on axons and/or terminals of primary sensory neurons, where they mediate …

Over the past three decades the research on GABA B receptor biology and pharmacology in
pain processing has been a fascinating experience. Norman Bowery's fundamental …

Decades of research have been devoted to defining the role of GABAergic transmission in
nociceptive processing. Much of this work was performed using rigid, orthosteric GABA …

One feature of neuropathic pain is a reduced GABAergic inhibitory function. Nociceptors
have been suggested to play a key role in this process. However, the mechanisms behind …