Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
The collaborative study on the genetics of alcoholism: Brain function
Alcohol use disorder (AUD) and related health conditions result from a complex interaction
of genetic, neural and environmental factors, with differential impacts across the lifespan …
of genetic, neural and environmental factors, with differential impacts across the lifespan …
Are novel treatments for brain disorders hiding in plain sight?
L Duncan, K Deisseroth - Neuropsychopharmacology, 2024 - nature.com
Psychiatric diseases are strongly influenced by genetics, but genetically guided treatments
have been slow to develop, and precise molecular mechanisms remain mysterious …
have been slow to develop, and precise molecular mechanisms remain mysterious …
Alcohol intake and cause-specific mortality: conventional and genetic evidence in a prospective cohort study of 512 000 adults in China
Background Genetic variants that affect alcohol use in East Asian populations could help
assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to …
assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to …
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes
Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviours and although strides have been made using …
Genetic factors influence smoking behaviours and although strides have been made using …
Rare coding variants in CHRNB2 reduce the likelihood of smoking
VM Rajagopal, K Watanabe, J Mbatchou, A Ayer… - Nature Genetics, 2023 - nature.com
Human genetic studies of smoking behavior have been thus far largely limited to common
variants. Studying rare coding variants has the potential to identify drug targets. We …
variants. Studying rare coding variants has the potential to identify drug targets. We …
Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …
than others. Understanding the shared genetic influences underlying the comorbidity …
Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk
Background Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but
the complex relationship and the potential pathway are not fully understood. Methods We …
the complex relationship and the potential pathway are not fully understood. Methods We …
An approach to identify gene-environment interactions and reveal new biological insight in complex traits
X Zhu, Y Yang, N Lorincz-Comi, G Li… - Nature …, 2024 - nature.com
There is a long-standing debate about the magnitude of the contribution of gene-
environment interactions to phenotypic variations of complex traits owing to the low …
environment interactions to phenotypic variations of complex traits owing to the low …