RPE cells are the most actively phagocytic cells in the human body. In the eye, RPE cells
face rod and cone photoreceptor outer segments at all times but contribute to shedding and …

Age-related macular degeneration (AMD) remains a major cause of blindness, with
dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We …

Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …

Considerable progress has been made in testing stem cell–derived retinal pigment
epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD) …

Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological
changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily …

Primary cilia are sensory organelles that protrude from the cell membrane. Defects in the
primary cilium cause ciliopathy disorders, with retinal degeneration as a prominent …

The mammalian retina contains multiple cellular layers, each carrying out a specific task.
Such a controlled organization should be considered as a crucial factor for designing retinal …

Induced pluripotent stem cells (iPSCs) can be efficiently differentiated into retinal pigment
epithelium (RPE), offering the possibility of autologous cell replacement therapy for retinal …

Dry age-related macular degeneration (AMD) is marked by the accumulation of extracellular
and intracellular lipid-rich deposits within and around the retinal pigment epithelium (RPE) …

Age-related macular degeneration (AMD) is a complex disease caused by different genetic
and environmental risk factors leading to loss of cells in the central part of the retina …