The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

Nuclear DNA wraps around core histones to form nucleosomes, which restricts the binding
of transcription factors to gene regulatory sequences. Pioneer transcription factors can bind …

Chromatin modifications are associated with many aspects of gene expression, yet their role
in cellular transitions during development remains elusive. Here, we use a new approach to …

INTRODUCTION The circadian clock is a molecular oscillator that coordinates behavior and
physiology in anticipation of the daily light cycle. Desynchrony of circadian cycles, through …

Background Insulin producing beta cell and glucagon producing alpha cells are colocalized
in pancreatic islets in an arrangement that facilitates the coordinated release of the two …

Combinations of post‐translational histone modifications shape the chromatin landscape
during cell development in eukaryotes. However, little is known about the modifications …

Monomethylation of lysine 4 on histone H3 (H3K4me1) is a well-established feature of
enhancers and promoters, although its function is unknown. Here, we uncover roles for …

To understand how transcription factors function, it is essential to determine the range of
genes that they each bind and regulate in vivo. Here I review evidence that most animal …

Background While most cells in multicellular organisms carry the same genetic information,
in each cell type only a subset of genes is being transcribed. Such differentiation in gene …