Structural diversity of G protein-coupled receptors and significance for drug discovery

MC Lagerström, HB Schiöth - Nature reviews Drug discovery, 2008 - nature.com
G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Mutant G-protein-coupled receptors as a cause of human diseases

T Schöneberg, A Schulz, H Biebermann… - Pharmacology & …, 2004 - Elsevier
G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

G protein-coupled receptor-dependent development of human frontal cortex

X Piao, RS Hill, A Bodell, BS Chang… - Science, 2004 - science.org
The mammalian cerebral cortex is characterized by complex patterns of anatomical and
functional areas that differ markedly between species, but the molecular basis for this …

Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands

P Joost, A Methner - Genome biology, 2002 - Springer
Background G-protein-coupled receptors (GPCRs) are the largest and most diverse family of
transmembrane receptors. They respond to a wide range of stimuli, including small peptides …

Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a Gα12/13 and Rho pathway

T Iguchi, K Sakata, K Yoshizaki, K Tago… - Journal of Biological …, 2008 - ASBMB
In the developing forebrain, the migration and positioning of neural progenitor cells (NPCs)
are regulated coordinately by various molecules. Mutation of these molecules, therefore …

Dynamic Regulation of a GPCR-Tetraspanin-G Protein Complex on Intact Cells: Central Role of CD81 in Facilitating GPR56-Gαq/11 Association

KD Little, ME Hemler, CS Stipp - Molecular biology of the cell, 2004 - Am Soc Cell Biol
By means of a variety of intracellular scaffolding proteins, a vast number of heterotrimeric G
protein–coupled receptors (GPCRs) may achieve specificity in signaling through a much …

[HTML][HTML] The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes

M Hinckley, S Vaccari, K Horner, R Chen, M Conti - Developmental biology, 2005 - Elsevier
In mammalian and amphibian oocytes, the meiotic arrest at the G2/M transition is dependent
on cAMP regulation. Because genetic inactivation of a phosphodiesterase expressed in …

From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs

AV Terskikh, MC Easterday, L Li… - Proceedings of the …, 2001 - National Acad Sciences
It is reasonable to propose that gene expression profiles of purified stem cells could give
clues for the molecular mechanisms of stem cell behavior. We took advantage of cDNA …

GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion

S Shashidhar, G Lorente, U Nagavarapu, A Nelson… - Oncogene, 2005 - nature.com
GPR56 (also known as TM7XN1) is a newly discovered orphan G-protein-coupled receptor
(GPCR) of the secretin family that has a role in the development of neural progenitor cells …

Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility

B Davies, C Baumann, C Kirchhoff, R Ivell… - … and cellular biology, 2004 - Taylor & Francis
Human epididymal protein 6 (HE6; also known as GPR64) is an orphan member of the LNB-
7TM (B2) subfamily of G-protein-coupled receptors. Family members are characterized by …