The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Organelles form tight connections through membrane contact sites, thereby cooperating to
regulate homeostasis and cell function. Among them, the contact between endoplasmic …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

The endoplasmic reticulum (ER) is the largest organelle of the cell, composed of a
continuous network of sheets and tubules, and is involved in protein, calcium (Ca 2+), and …

Background Hypoxic pulmonary hypertension (HPH) is a chronic progressive advanced
disorder pathologically characterized by pulmonary vascular remodeling. Notch4 as a cell …

Mitochondria are the primary source of energy production in neurons, supporting the high
energy consumption of the nervous system. Inefficient and dysfunctional mitochondria in the …

The Notch signaling pathway is a key regulator of skeletal muscle development and
regeneration. Over the past decade, the discoveries of three new muscle disease genes …

The marine environment is highly diverse, each living creature fighting to establish and
proliferate. Among marine organisms, cyanobacteria are astounding secondary metabolite …

Peptide-drug conjugates (PDCs) are the new hope for targeted therapy after antibody-drug
conjugates (ADCs). Compared with ADCs, the core advantages of PDCs are enhanced …

We have used FRET-based biosensors in live cells, in a robust high-throughput screening
(HTS) platform, to identify small-molecules that alter the structure and activity of the cardiac …