Strategies for Enhancing Non-small Cell Lung Cancer Treatment: Integrating Chinese Herbal Medicines with Epidermal Growth Factor Receptor-Tyrosine Kinase …
L Chen, WD Chen, YX Xu, YY Ren, C Zheng… - European Journal of …, 2024 - Elsevier
Non-small cell lung cancer (NSCLC) poses a global health threat, and epidermal growth
factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib, afatinib, and …
factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib, afatinib, and …
Notch induces transcription by stimulating release of paused RNA polymerase II
Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that
influences a wide range of cellular processes by regulating transcription. Despite years of …
influences a wide range of cellular processes by regulating transcription. Despite years of …
Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
L Tveriakhina, G Scanavachi, ED Egan… - Developmental Cell, 2024 - cell.com
Mammalian Notch signaling occurs when the binding of Delta or Jagged to Notch stimulates
the proteolytic release of the Notch intracellular domain (NICD), which enters the nucleus to …
the proteolytic release of the Notch intracellular domain (NICD), which enters the nucleus to …
Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity
Q Dai, K Preusse, D Yu, RA Kovall, K Thorner… - PLoS …, 2024 - journals.plos.org
A tri-protein complex containing NICD, RBPj and MAML1 binds DNA as monomer or as
cooperative dimers to regulate transcription. Mice expressing N otch d imerization-d eficient …
cooperative dimers to regulate transcription. Mice expressing N otch d imerization-d eficient …
Notch induces transcription by stimulating release of paused RNA Polymerase II
Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that
influences a wide range of cellular processes by regulating transcription. Despite years of …
influences a wide range of cellular processes by regulating transcription. Despite years of …
Notch Interaction with Glycogen Synthase Kinase-3β in Neurodegenerative Disease
T Traub - 2024 - dspace.cuni.cz
Glycogen synthase kinase-3βeta (GSK-3β) is a serine/threonine protein kinase involved in a
number of signaling processes. Pharmacological inhibition of GSK-3β has been shown to …
number of signaling processes. Pharmacological inhibition of GSK-3β has been shown to …