Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

The skin is a unique immune organ that constitutes a complex network of physical, chemical
and microbiological barriers against external insults. Keratinocytes are the most abundant …

Increased expression of Th22 cytokine IL-22 is a characteristic finding in atopic dermatitis
(AD). However, the specific role of IL-22 in the pathogenesis of AD in vivo has yet to be …

Cytokines play an important role in the regulation of the immune system (adaptive and
innate). Given their importance in proinflammatory processes, cytokines have been used for …

Stem and progenitor cells of the submandibular salivary gland (SMG) give rise to, maintain,
and regenerate the multiple lineages of mature epithelial cells including those belonging to …

Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted
increasing attention from scholars since it was confirmed in the human body. In the human …

As a member of tumor suppressor p53 family, p63, a gene encoding versatile protein variant,
has been documented to correlate with cancer formation and progression, though it is rarely …

Salivary glands consist of several epithelial cell types of distinct lineages and functional
characteristics that are established by directed differentiation programs of resident stem and …

Air pollution has been linked to many health issues, including skin conditions, especially in
children. Among all the atmospheric pollutants, ultrafine particles have been deemed very …

Multipotent ΔNp63-positive cells maintain all epithelial cell lineages of the embryonic and
adult salivary gland (SG). However, the molecular mechanisms by which ΔNp63 regulates …