Intestinal anti-inflammatory activity of terpenes in experimental models (2010–2020): A review

ME Araruna, C Serafim, E Alves Junior, C Hiruma-Lima… - Molecules, 2020 - mdpi.com
Inflammatory bowel diseases (IBDs) refer to a group of disorders characterized by
inflammation in the mucosa of the gastrointestinal tract, which mainly comprises Crohn's …

Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the …

M Ghasemi-Dehnoo, H Amini-Khoei, Z Lorigooini… - …, 2023 - Springer
Introduction Ulcerative colitis is a chronic inflammation of the colon. However, the common
treatment for it is accompanied by many complications. Therefore, the present study was …

Preventive effect of lycopene in dextran sulfate sodium-induced ulcerative colitis mice through the regulation of TLR4/TRIF/NF-κB signaling pathway and tight …

Y Li, X Pan, M Yin, C Li, L Han - Journal of Agricultural and Food …, 2021 - ACS Publications
The preventive effect and molecular mechanism of lycopene (LP) in dextran sulfate sodium
(DSS)-induced ulcerative colitis (UC) in mice were evaluated. Compared to the DSS group …

Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases

MA Didamoony, AA Soubh, AM Atwa, LA Ahmed - Inflammopharmacology, 2023 - Springer
Gastrointestinal (GI) diseases have become a global health issue and an economic burden
due to their wide distribution, late prognosis, and the inefficacy of recent available …

Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice

OA Ahmedy, SM Ibrahim, HH Salem… - Chemico-biological …, 2020 - Elsevier
Ulcerative colitis (UC) is a chronic disease driven primarily by uncontrolled pervasive
inflammatory responses affecting the colon and rectum. Currently available medications …

Targeting endoplasmic reticulum stress, Nrf-2/HO-1, and NF-κB by myristicin and its role in attenuation of ulcerative colitis in rats

HMIA El-Fadl, MFA Mohamed - Life Sciences, 2022 - Elsevier
Aims Ulcerative colitis (UC) is characterized by the up-regulation of pro-inflammatory
mediators, apoptotic signals, and oxidative stress that can lead to an increased risk of …

Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis

WA El-Dakroury, MB Zewail, GF Asaad… - European Journal of …, 2024 - Elsevier
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles
(SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a …

Graviola mitigates acetic acid–induced ulcerative colitis in rats: insight on apoptosis and Wnt/Hh signaling crosstalk

MG Helal, AG Abd Elhameed - Environmental Science and Pollution …, 2021 - Springer
In this study, we elucidated the potential protective effects of graviola leaves, compared with
sulfasalazine, against acetic acid (AA)–induced ulcerative colitis (UC) in rats. Twenty-eight …

[HTML][HTML] Immunomodulatory assessment of Portulaca oleracea L. extract in a mouse model of colitis

MA Alfwuaires, AI Algefare, E Afkar, SA Salam… - Biomedicine & …, 2021 - Elsevier
Ulcerative colitis (UC) is a gastrointestinal inflammatory disease with a multifactorial
pathophysiology. This study aims to investigate the immunomodulatory effect of Portulaca …

Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into TLR4/NF-kB/caspase signalling modulation

M El-Sherbiny, NH Eisa, NFA El-Magd… - Environmental …, 2021 - Elsevier
Ulcerative colitis (UC) is an inflammatory bowel disease with limited therapeutic
management approaches. The present study evaluated the potential therapeutic impact of …