The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

The nitrile or cyano (–CN) group is one of the most appreciated and effective functional
groups in organic synthesis, having a polar unsaturated C–N triple bond. Despite sufficient …

A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …

This paper describes for the first time an efficient approach to synthesize a novel
trifluoromethylated heterocyclic system of seventeen examples of substituted …

A new method for converting easy availability starting materials 2-(2-oxoindolin-3-yl)
acetonitrile, arylboronic acids, and alcohols into 2-arylquinoline-4-carboxylates is reported …

A novel series of fluorine‐containing quinoline hybrid thiosemicarbazide analogues (8a–8l)
were synthesized and tested for their biological activities. The antibacterial results …

This paper describes firstly an effective protocol for the synthesis of a new series of five
examples of 3-(trifluoromethyl)-3, 3a-dihydrospiro [chromeno [4, 3-c] isoxazole-4, 1 …

This paper describes the synthesis of a novel series of 2-aryl-6-(1H-indol-1-yl)-4-
(trifluoromethyl) quinolines, in which aryl= C 6 H 5, 4-CH 3 C 6 H 4, 4-FC 6 H 4, 4-CF 3 C 6 …

The regioselective synthesis of twenty novel [3-substituted 5-hydroxy-5-(trifluoromethyl)-4, 5-
dihydro-1H-pyrazol-1-yl][6-aryl-(2-methylthio) pyrimidin-4-yl] methanones from the …

In the recent decade, the study on N-heterocycles has dramatically increased due to its
versatility in many significant fields and because of its distinctive battle which is associated …