Chemiosmotic and murburn explanations for aerobic respiration: predictive capabilities, structure-function correlations and chemico-physical logic
Since mid-1970s, the proton-centric proposal of 'chemiosmosis' became the acclaimed
explanation for aerobic respiration. Recently, significant theoretical and experimental …
explanation for aerobic respiration. Recently, significant theoretical and experimental …
[HTML][HTML] Structural foundations for explaining the physiological roles of murzymes embedded in diverse phospholipid membranes
The advent of improved structural biology protocols and bioinformatics methodologies have
provided paradigm-shifting insights on metabolic or physiological processes catalyzed by …
provided paradigm-shifting insights on metabolic or physiological processes catalyzed by …
[HTML][HTML] Herbal concoction unveiled: a computational analysis of phytochemicals' pharmacokinetic and toxicological profiles using novel approach methodologies …
Herbal medications have an extensive history of use in treating various diseases, attributed
to their perceived efficacy and safety. Traditional medicine practitioners and contemporary …
to their perceived efficacy and safety. Traditional medicine practitioners and contemporary …
Aerobic respiration: Criticism of the proton-centric explanation involving rotary adenosine triphosphate synthesis, chemiosmosis principle, proton pumps and electron …
KM Manoj - Biochemistry insights, 2018 - journals.sagepub.com
The acclaimed explanation for mitochondrial oxidative phosphorylation (mOxPhos, or
cellular respiration) is a deterministic proton-centric scheme involving four components …
cellular respiration) is a deterministic proton-centric scheme involving four components …
Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation
The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological
regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition …
regimes) is demonstrated with an assessment of thermodynamics, kinetics, and inhibition …
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
It is unresolved why lactate is transported to the liver for further utilization within the
physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) …
physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) …
Aerobic respiration: proof of concept for the oxygen-centric murburn perspective
KM Manoj, A Parashar, V David Jacob… - Journal of …, 2019 - Taylor & Francis
The inner mitochondrial membrane protein complexes (I–V) and prokaryotic respiratory
machinery are examined for a deeper understanding of their structure–function correlations …
machinery are examined for a deeper understanding of their structure–function correlations …
Validating the predictions of murburn model for oxygenic photosynthesis: Analyses of ligand-binding to protein complexes and cross-system comparisons
In this second half of our treatise on oxygenic photosynthesis, we provide support for the
murburn model of the light reaction of photosynthesis and ratify key predictions made in the …
murburn model of the light reaction of photosynthesis and ratify key predictions made in the …
Murburn precepts for cytochrome P450 mediated drug/xenobiotic metabolism and homeostasis
A Parashar, KM Manoj - Current Drug Metabolism, 2021 - benthamdirect.com
Aims: We aim to demonstrate why deeming diffusible reactive oxygen species (DROS) as
toxic wastes do not afford a comprehensive understanding of cytochrome P450 mediated …
toxic wastes do not afford a comprehensive understanding of cytochrome P450 mediated …
Why do cells need oxygen? Insights from mitochondrial composition and function
Mitochondrial membrane‐embedded redox proteins are classically perceived as
deterministic “electron transport chain”(ETC) arrays cum proton pumps; and oxygen is seen …
deterministic “electron transport chain”(ETC) arrays cum proton pumps; and oxygen is seen …