In the past decades, bacterial cell-cell communication has captivated interest of a broad
scientific community drawn from a wide spectrum of disciplines including biology, physics …

One fundamental challenge in synthetic biology is the lack of quantitative tools that
accurately describe and predict the behaviours of engineered gene circuits. This challenge …

A promising alternative for unraveling the principles under which the dynamic interactions
among genes lead to cellular phenotypes relies on mathematical and computational models …

Quantitative modeling of gene circuits is fundamentally important to synthetic biology, as it
offers the potential to transform circuit engineering from trial-and-error construction to …

Complex feedback systems are ubiquitous in biology. Modeling such systems with mass
action laws or master equations requires information rarely measured directly. Thus rates …

Background In cell signaling terminology, adaptation refers to a system's capability of
returning to its equilibrium upon a transient response. To achieve this, a network has to be …

This plenary talk is to review our studies on mathematical modelling of complex systems and
its possible applications, which have been carried out by the Aihara Complexity Modelling …