Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Low-protein diets promote metabolic health in rodents and humans, and the benefits of low-
protein diets are recapitulated by specifically reducing dietary levels of the three branched …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Protein-restricted diets promote health and longevity in many species. While the precise
components of a protein-restricted diet that mediate the beneficial effects to longevity have …

Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …

Recent studies have suggested that the intestinal microbiome plays an important role in
modulating risk of several chronic diseases, including inflammatory bowel disease, obesity …

BACKGROUND Reduced caloric intake without malnutrition is the oldest known life span–
extending intervention. Laboratory studies throughout the 20th century established and …

Objective To examine and quantify the potential dose-response relation between intake of
total, animal, and plant protein and the risk of mortality from all causes, cardiovascular …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …