The direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban, and edoxaban,
are becoming the most commonly prescribed drugs for preventing ischemic stroke in …

Background Fluid retention and endothelial dysfunction have been related to use of
nonsteroidal anti-inflammatory drugs (NSAIDs), and type 2 diabetes mellitus (T2DM) has …

Abstract Study Objective The aim of this study was to evaluate the effect on bleeding risk
when fluconazole is administered concomitantly with direct oral anticoagulants (DOACs) …

To study the effects of metabolic enzyme activity inhibition and genetic polymorphisms on
the pharmacokinetics and pharmacodynamics of rivaroxaban, we established an in vitro …

The management of the drug-drug interaction (DDI) between primidone, a moderate to
strong cytochrome P-450 (CYP) 3A4 inducer, and apixaban, a direct oral anticoagulant …

We conducted a single-center, retrospective, cohort study of 50 adult patients (≥ 18 years
old) with acute leukemia or high-risk myelodysplastic syndrome (MdS) on apixaban …

Background Candidemia is the fourth most common nosocomial bloodstream infection.
Endocarditis from candidemia is a rare but possibly fatal complication. The efficacy of …

objetivo: Fornecer informações sobre as principais alterações fisiológicas que podem
influenciar as propriedades farmacológicas em pacientes críticos e das interações …

No ambiente hospitalar, principalmente em unidades de terapia intensiva, as infecções
fúngicas oportunistas representam um grande desafio a comunidade médica e científica …

Hemostaza je fiziološki proces zaustavljanja krvarenja. U slučaju prokoagulantno narušene
hemostatske ravnoteže nastaje tromboza. Antikoagulantni lijekovi omogućuju prevenciju i …