Sp1 and the 'hallmarks of cancer'
K Beishline, J Azizkhan‐Clifford - The FEBS journal, 2015 - Wiley Online Library
For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …
Histone acetyltransferases
▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …
Mistimed sleep disrupts circadian regulation of the human transcriptome
Circadian organization of the mammalian transcriptome is achieved by rhythmic recruitment
of key modifiers of chromatin structure and transcriptional and translational processes …
of key modifiers of chromatin structure and transcriptional and translational processes …
[HTML][HTML] Focus: Epigenetics: The role of the ubiquitously expressed transcription factor Sp1 in tissue-specific transcriptional regulation and in disease
L O'Connor, J Gilmour, C Bonifer - The Yale journal of biology and …, 2016 - ncbi.nlm.nih.gov
Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm
for a ubiquitously expressed transcription factor and is involved in regulating the expression …
for a ubiquitously expressed transcription factor and is involved in regulating the expression …
The role of Sp1 and Sp3 in normal and cancer cell biology
L Li, JR Davie - Annals of Anatomy-Anatomischer Anzeiger, 2010 - Elsevier
Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are
involved in regulating the transcriptional activity of genes implicated in most cellular …
involved in regulating the transcriptional activity of genes implicated in most cellular …
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
S Kyo, M Takakura, T Fujiwara, M Inoue - Cancer science, 2008 - Wiley Online Library
Telomerase activation is a critical step for human carcinogenesis through the maintenance
of telomeres, but the activation mechanism during carcinogenesis remains unclear …
of telomeres, but the activation mechanism during carcinogenesis remains unclear …
Sp1 phosphorylation and its regulation of gene transcription
NY Tan, LM Khachigian - Molecular and cellular biology, 2009 - Taylor & Francis
Sp1 is a ubiquitously expressed, prototypic C2H2-type zinc finger-containing DNA binding
protein that can activate or repress transcription in response to physiologic and pathological …
protein that can activate or repress transcription in response to physiologic and pathological …
Keep your fingers off my DNA: protein–protein interactions mediated by C2H2 zinc finger domains
Abstract Cys2-His2 (C2H2) zinc finger domains (ZFs) were originally identified as DNA-
binding domains, and uncharacterized domains are typically assumed to function in DNA …
binding domains, and uncharacterized domains are typically assumed to function in DNA …
Gene regulation by Sp1 and Sp3
L Li, S He, JM Sun, JR Davie - Biochemistry and Cell Biology, 2004 - cdnsciencepub.com
La famille de facteurs de transcription Sp partage une combinaison particulière de trois
motifs à doigts de zinc Cys2His2 qui forment le domaine spécifique de liaison à l'ADN. Au …
motifs à doigts de zinc Cys2His2 qui forment le domaine spécifique de liaison à l'ADN. Au …
RSAT peak-motifs: motif analysis in full-size ChIP-seq datasets
M Thomas-Chollier, C Herrmann… - Nucleic acids …, 2012 - academic.oup.com
ChIP-seq is increasingly used to characterize transcription factor binding and chromatin
marks at a genomic scale. Various tools are now available to extract binding motifs from …
marks at a genomic scale. Various tools are now available to extract binding motifs from …