IgG4-related conditions affecting the digestive tract are part of a multi-organ fibro-
inflammatory disorder termed IgG4-related disease (IgG4-RD), with autoimmune pancreatitis …

Pemphigus is a rare autoimmune disease that results in blistering of the skin and oral cavity.
It is caused by autoantibodies directed against cell-surface antigens on keratinocytes, which …

Background Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by
irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the …

BACKGROUND & AIMS: Autoimmune pancreatitis is a distinctive disease entity
characterized by high serum immunoglobulin G4 concentrations. Because of the close …

Mutations in SPINK5, encoding the serine protease inhibitor LEKTI, cause Netherton
syndrome, a severe autosomal recessive genodermatosis. Spink5−/− mice faithfully …

Much of the original research on desmosomes and their biochemical components was
through analysis of skin and mucous membranes. The identification of desmogleins 1 and 3 …

Background Pemphigus vulgaris (PV) and foliaceus (PF) are characterized by antibodies to
the desmosomal proteins desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), respectively. Past …

Pemphigus is a group of potentially life-threatening diseases characterized by cutaneous
and mucosal blistering. There is a fairly strong genetic background to pemphigus with …

Autoimmune pancreatitis typically produces an enlarged pancreas with narrowing of the
pancreatic duct, and can mimic carcinoma. Autoimmune pancreatitis usually responds to …

Pemphigus is a life-threatening blistering disorder of the skin and mucous membranes
caused by pathogenic autoantibodies to desmosomal adhesion proteins desmoglein 3 …