The role of macrophages in cancer development and therapy

E Cendrowicz, Z Sas, E Bremer, TP Rygiel - Cancers, 2021 - mdpi.com
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …

Nanotechnology in ovarian cancer: Diagnosis and treatment

M Barani, M Bilal, F Sabir, A Rahdar, GZ Kyzas - Life Sciences, 2021 - Elsevier
To overcome the drawbacks of conventional delivery, this review spotlights a number of
nanoscale drug delivery systems, including nanoparticles, liposomes, nano micelles …

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

AA Barkal, RE Brewer, M Markovic, M Kowarsky… - Nature, 2019 - nature.com
Ovarian cancer and triple-negative breast cancer are among the most lethal diseases
affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are …

Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

ML Doolittle, D Saul, J Kaur, JL Rowsey, SJ Vos… - Nature …, 2023 - nature.com
Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

M Majidinia, M Mirza‐Aghazadeh‐Attari, M Rahimi… - IUBMB …, 2020 - Wiley Online Library
Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both
conventional and novel chemotherapy agents, is an important barrier in treating …

Macrophage‐mediated tumor cell phagocytosis: opportunity for nanomedicine intervention

X Zhou, X Liu, L Huang - Advanced functional materials, 2021 - Wiley Online Library
Macrophages are one of the most abundant non‐malignant cells in the tumor
microenvironment, playing critical roles in mediating tumor immunity. As important innate …

Diversity of immune checkpoints in cancer immunotherapy

Z Guo, R Zhang, AG Yang, G Zheng - Frontiers in Immunology, 2023 - frontiersin.org
Finding effective treatments for cancer remains a challenge. Recent studies have found that
the mechanisms of tumor evasion are becoming increasingly diverse, including abnormal …

Macrophages as a “weapon” in anticancer cellular immunotherapy

D Aminin, YM Wang - The Kaohsiung Journal of Medical …, 2021 - Wiley Online Library
Anticancer immunotherapy is a treatment that activates the immune system to fight the tumor.
Immunotherapy has several advantages over other cancer treatments in that anticancer …

MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

M Abolghasemi, SS Tehrani, T Yousefi… - Journal of cellular …, 2020 - Wiley Online Library
Breast cancer is one of the most lethal malignancies in women in the world. Various factors
are involved in the development and promotion of the malignancy; most of them involve …

Tuning nanoparticle interactions with ovarian cancer through layer-by-layer modification of surface chemistry

S Correa, N Boehnke, AE Barberio, E Deiss-Yehiely… - Acs Nano, 2020 - ACS Publications
Nanoparticle surface chemistry is a fundamental engineering parameter that governs tumor-
targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes …