Towards translational optogenetics
Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …
Therapeutic AAV gene transfer to the nervous system: a clinical reality
E Hudry, LH Vandenberghe - Neuron, 2019 - cell.com
Gene transfer has long been a compelling yet elusive therapeutic modality. First mainly
considered for rare inherited disorders, gene therapy may open treatment opportunities for …
considered for rare inherited disorders, gene therapy may open treatment opportunities for …
Cochlear implant research and development in the twenty-first century: a critical update
RP Carlyon, T Goehring - Journal of the Association for Research in …, 2021 - Springer
Cochlear implants (CIs) are the world's most successful sensory prosthesis and have been
the subject of intense research and development in recent decades. We critically review the …
the subject of intense research and development in recent decades. We critically review the …
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents
D Keppeler, M Schwaerzle, T Harczos… - Science Translational …, 2020 - science.org
When hearing fails, electrical cochlear implants (eCIs) provide the brain with auditory
information. One important bottleneck of CIs is the poor spectral selectivity that results from …
information. One important bottleneck of CIs is the poor spectral selectivity that results from …
Emerging approaches for restoration of hearing and vision
Impairments of vision and hearing are highly prevalent conditions limiting the quality of life
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …
and presenting a major socioeconomic burden. For a long time, retinal and cochlear …
Towards the optical cochlear implant: optogenetic approaches for hearing restoration
Cochlear implants (CI s) are considered the most successful neuroprosthesis as they enable
speech comprehension in the majority of half a million CI users suffering from sensorineural …
speech comprehension in the majority of half a million CI users suffering from sensorineural …
Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate
Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate
hearing and balance disorders. We previously established the benefits of Anc80L65 in …
hearing and balance disorders. We previously established the benefits of Anc80L65 in …
Viral rhodopsins 1 are an unique family of light-gated cation channels
Phytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and
thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that …
thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that …
AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear
Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary
deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even …
deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …