Tissue factor as an effector of angiogenesis and tumor progression in hematological malignancies

C Lopez-Pedrera, N Barbarroja, G Dorado… - Leukemia, 2006 - nature.com
In the last few years, it has become clear that the processes of tumor angiogenesis,
metastasis and invasiveness are highly dependent on components of the blood coagulation …

Bridging proteomics and systems biology: what are the roads to be traveled?

S Souchelnytskyi - Proteomics, 2005 - Wiley Online Library
The comprehensive study of proteomes has become an important part of attempts to
uncover the systemic properties of biological systems. Proteomics provides data of a quality …

2‐DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)

R Hoffrogge, S Mikkat, C Scharf, S Beyer… - …, 2006 - Wiley Online Library
The proteome of a proliferating human stem cell line was analyzed and then utilized to
detect stem cell differentiation‐associated changes in the protein profile. The analysis was …

Proteomic analysis of acute myeloid leukemia: Identification of potential early biomarkers and therapeutic targets

C López‐Pedrera, JM Villalba, E Siendones… - …, 2006 - Wiley Online Library
The main goal of this study was to analyze, using proteomic techniques, changes in protein
expression of acute myeloid leukemia (AML) cells that could give insights into a better early …

Overexpression of sorcin in multidrug resistant human leukemia cells and its role in regulating cell apoptosis

J Qi, N Liu, Y Zhou, Y Tan, Y Cheng, C Yang… - Biochemical and …, 2006 - Elsevier
In an attempt to identify novel proteins involved in the emergence of multidrug resistance
(MDR) in leukemia cells, we adopted a proteomics approach to analyze protein expression …

Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPα by inhibiting its ubiquitination

AK Trivedi, D Bararia, M Christopeit, AA Peerzada… - Oncogene, 2007 - nature.com
Functional inactivation of transcription factors in hematopoietic stem cell development is
involved in the pathogenesis of acute myeloid leukemia (AML). Stem cell regulator …

Characterization of transcription factors by mass spectrometry and the role of SELDI‐MS

CE Forde… - Mass spectrometry …, 2002 - Wiley Online Library
Abstract I. Introduction 419 II. Genomics, Proteomics, and MS 420 III. Regulatory Networks
and the Traditional Study of Transcription Factors 421 IV. Identification of Transcription …

2‐DE profiling of GDNF overexpression‐related proteome changes in differentiating ST14A rat progenitor cells

R Hoffrogge, S Beyer, R Hübner, S Mikkat, E Mix… - …, 2007 - Wiley Online Library
Targeted differentiation of neural progenitor cells (NPCs) is a challenge for treatment of
neurodegenerative diseases by cell replacement therapy and cell signalling manipulation …

Multiple ways of C/EBPα inhibition in myeloid leukaemia

AK Trivedi, P Pal, G Behre, SM Singh - European Journal of Cancer, 2008 - Elsevier
Transcription factors play a crucial role in myeloid differentiation and lineage determination.
Tumour suppressor protein C/EBPα is a key regulator of granulocytic differentiation whose …

Klassifikation der Leukämien und malignen Lymphome

D Reinhardt, J Ritter - Pädiatrische Hämatologie und Onkologie, 2006 - Springer
Die 12-jährige Cornelia erkrankte mit Fieber und rezidivierenden Knochenschmerzen. Das
Blutbild zeigte eine Anämie und Thrombozytopenie. Bei Verdacht auf Leukämie wurde eine …