Mapping the iceberg of autonomic recovery: mechanistic underpinnings of neuromodulation following spinal cord injury

S Samejima, C Shackleton, T Miller… - The …, 2024 - journals.sagepub.com
Spinal cord injury leads to disruption in autonomic control resulting in cardiovascular, bowel,
and lower urinary tract dysfunctions, all of which significantly reduce health-related quality of …

[HTML][HTML] Improvements in bladder function following activity-based recovery training with epidural stimulation after chronic spinal cord injury

AN Herrity, SC Aslan, B Ugiliweneza… - Frontiers in systems …, 2021 - frontiersin.org
Spinal cord injury (SCI) results in profound neurologic impairment with widespread deficits
in sensorimotor and autonomic systems. Voluntary and autonomic control of bladder …

[HTML][HTML] Non-invasive neuromodulation of spinal cord restores lower urinary tract function after paralysis

PN Gad, E Kreydin, H Zhong, K Latack… - Frontiers in …, 2018 - frontiersin.org
It is commonly assumed that restoration of locomotion is the ultimate goal after spinal cord
injury (SCI). However, lower urinary tract (LUT) dysfunction is universal among SCI patients …

Spinal interneurons of the lower urinary tract circuits

S Karnup - Autonomic Neuroscience, 2021 - Elsevier
The storage and elimination of urine requires coordinated activity between muscles of the
bladder and the urethra. This coordination is orchestrated by a complex system containing …

[HTML][HTML] Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury

AN Herrity, SC Aslan, S Mesbah, R Siu, K Kalvakuri… - Scientific reports, 2022 - nature.com
Profound dysfunctional reorganization of spinal networks and extensive loss of functional
continuity after spinal cord injury (SCI) has not precluded individuals from achieving …

Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats

V Pikov, DB McCreery, M Han - Journal of neural engineering, 2020 - iopscience.iop.org
Objective. Bladder dysfunction is a significant and largely unaddressed problem for people
living with spinal cord injury (SCI). Intermittent catheterization does not provide volitional …

Epidural Spinal Stimulation Enables Global Sensorimotor and Autonomic Function Recovery After Complete Paralysis: 1st Study From India

S Kandhari, D Sharma, S Samuel… - … on Neural Systems …, 2022 - ieeexplore.ieee.org
While the loss of sensorimotor and autonomic function often occurs due to multiple trauma
and pathologies, spinal cord injury is one of the few traumatic pathologies that severely …

Propriospinal neurons of L3-L4 segments involved in control of the rat external urethral sphincter

SV Karnup, WC de Groat - Neuroscience, 2020 - Elsevier
Coordination of activity of external urethral sphincter (EUS) striated muscle and bladder (BL)
smooth muscle is essential for efficient voiding. In this study we examined the morphological …

Mapping and neuromodulation of lower urinary tract function using spinal cord stimulation in female rats

HH Chang, JC Yeh, RM Ichiyama, LV Rodriguez… - Experimental …, 2018 - Elsevier
Spinal cord epidural stimulation (SCS) represents a form of neuromodulation for the
management of spasticity and pain. This technology has recently emerged as a new …

[HTML][HTML] Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model

Y Sysoev, E Bazhenova, P Shkorbatova, G Kovalev… - Scientific Reports, 2024 - nature.com
Several neurologic diseases including spinal cord injury, Parkinson's disease or multiple
sclerosis are accompanied by disturbances of the lower urinary tract functions. Clinical data …