Roles and regulation of tRNA-derived small RNAs in animals

S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …

Roles of noncoding RNAs in regulation of mitochondrial electron transport chain and oxidative phosphorylation

A Kobayashi, T Takeiwa, K Ikeda, S Inoue - International Journal of …, 2023 - mdpi.com
The mitochondrial electron transport chain (ETC) plays an essential role in energy
production by inducing oxidative phosphorylation (OXPHOS) to drive numerous biochemical …

[HTML][HTML] Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control

P Schult, BM Kümmerer, M Hafner, K Paeschke - Cell Host & Microbe, 2024 - cell.com
Viral genomes are enriched with G-quadruplexes (G4s), non-canonical structures formed in
DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of …

Identification of RNA helicases with unwinding activity on angiogenin-processed tRNAs

A Drino, L König, C Capitanchik… - Nucleic Acids …, 2023 - academic.oup.com
Stress-induced tRNA fragmentation upon environmental insult is a conserved cellular
process catalysed by endonucleolytic activities targeting mature tRNAs. The resulting tRNA …

tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

F Brozzi, C Jacovetti, C Cosentino, V Menoud, K Wu… - Diabetologia, 2024 - Springer
Aims/hypothesis tRNAs play a central role in protein synthesis. Besides this canonical
function, they were recently found to generate non-coding RNA fragments (tRFs) regulating …

tRNA‐derived fragments are altered in diabetes

N Ng, HAY Gibriel, L Halang, E Jirström… - Diabetic …, 2024 - Wiley Online Library
Aims Maternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset
diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA …

The role of noncoding RNAs in beta cell biology and tissue engineering

J Zhu, X Zhu, Y Xu, X Chen, X Ge, Y Huang, Z Wang - Life Sciences, 2024 - Elsevier
The loss or dysfunction of pancreatic β-cells, which are responsible for insulin secretion,
constitutes the foundation of all forms of diabetes, a widely prevalent disease worldwide …

Evaluation of 5′-tRF-His-GTG As a Molecular Biomarker in Breast Cancer Diagnoses and Prognosis

X Tang, J Wu, Y Chen, D Wang, T Wang… - Cancer Biotherapy …, 2024 - liebertpub.com
Background: Breast cancer (BC) is the most prevalent cancer among women worldwide.
Although advances have been made in the identification of predictive biomarkers, current …

The diverse structural modes of tRNA binding and recognition

A Biela, A Hammermeister, I Kaczmarczyk… - Journal of Biological …, 2023 - ASBMB
tRNAs are short noncoding RNAs responsible for decoding mRNA codon triplets, delivering
correct amino acids to the ribosome, and mediating polypeptide chain formation. Due to their …

Expression profile of tsRNAs in white adipose tissue of vitamin D deficiency young male mice with or without obesity

Q Jia, Y Zhao - Scientific Reports, 2024 - nature.com
The expression of tsRNA in white adipose tissue (WAT) of VD deficiency male mice with
obesity has not been reported. The healthy male C57BL/6J mice aged 4-6 weeks were …