Emerging affinity methods for protein-drug interaction analysis
X Zheng, H Zhu, X Zhao, J Wang, Q Li… - Journal of Pharmaceutical …, 2024 - Elsevier
The study of protein-drug interaction plays a crucial role in understanding drug mechanisms,
identifying new drug targets and biomarkers, and facilitating drug development and disease …
identifying new drug targets and biomarkers, and facilitating drug development and disease …
[HTML][HTML] Recent advances in photoaffinity labeling strategies to capture Glycan–Protein interactions
JL Babulic, FVDL González, CJ Capicciotti - Current Opinion in Chemical …, 2024 - Elsevier
Glycans decorate all cells and are critical mediators of cellular processes through
recognition by glycan-binding proteins (GBPs). While targeting glycan–protein interactions …
recognition by glycan-binding proteins (GBPs). While targeting glycan–protein interactions …
Spot the difference in reactivity: a comprehensive review of site-selective multicomponent conjugation exploiting multi-azide compounds
H Tanimoto, T Tomohiro - Chemical Communications, 2024 - pubs.rsc.org
Going beyond the conventional approach of pairwise conjugation between two molecules,
the integration of multiple components onto a central scaffold molecule is essential for the …
the integration of multiple components onto a central scaffold molecule is essential for the …
Electrochemical C–H Azidation and Diazidation of Anilines for the Synthesis of Aryl Azides and Diazides
J Chen, X Feng, Q He, R Fan - The Journal of Organic Chemistry, 2024 - ACS Publications
The increasing importance and need in many aspects have driven the rapid development of
synthetic studies toward aryl azides. In this paper, electrochemical C–H azidation and …
synthetic studies toward aryl azides. In this paper, electrochemical C–H azidation and …
Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling
C Saintomé, O Monfret, G Doisneau, D Guianvarc'h - ChemBioChem - Wiley Online Library
A variety of proteins interact with DNA and RNA, including polymerases, histones,
ribosomes, transcription factors, and repair enzymes. However, the transient non‐covalent …
ribosomes, transcription factors, and repair enzymes. However, the transient non‐covalent …
A diazirine's central carbon is sp2-hybridized, facilitating conjugation to dye molecules
L Michelini, T Slaney, L Qie, K Corejova, ML Lepage… - 2024 - chemrxiv.org
Diazirines are versatile carbene precursors that are extensively used in biological target
identification experiments. However, their photo-activation wavelength (ca. 365 nm) …
identification experiments. However, their photo-activation wavelength (ca. 365 nm) …