Profiling approaches such as gene expression or proteome profiling generate small-
molecule bioactivity profiles that describe a perturbed cellular state in a rather unbiased …

Stereochemical and skeletal complexity are particularly important vis‐à‐vis the cross‐talks
between a small molecule and a complementary active site of a biological target. This …

Natural product structure and fragment-based compound development inspire pseudo-
natural product design through different combinations of a given natural product fragment …

Natural product (NP) structures are a rich source of inspiration for the discovery of new
biologically relevant chemical matter. In natural product inspired pseudo‐NPs, NP‐derived …

Robust, generalizable approaches to identify compounds efficiently with undesirable
mechanisms of action in complex cellular assays remain elusive. Such a process would be …

High-content image-based assays have fueled significant discoveries in the life sciences in
the past decade (2013–2023), including novel insights into disease etiology, mechanism of …

Small-molecule discovery typically involves large-scale screening campaigns, spanning
multiple compound collections. However, such activities can be cost-or time-prohibitive …

The escalating crisis of antimicrobial resistance (AMR) underscores the urgent need for
novel antimicrobials. One promising strategy is the exploration of structural diversity, as …

In today's world diversity is big challenge for not only organizations but also for educational
sector. Age, gender, professional and personality diversity has become important challenge …

Morphological Profiling of Small Molecules for Mode-of-Action Studies using the Cell Painting
Assay Page 1 Morphological Profiling of Small Molecules for Mode-of-Action Studies using …