Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Background Janus kinase (JAK) inhibitors, including baricitinib, block cytokine signaling and
are effective disease-modifying treatments for several autoimmune diseases. Whether …

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …

Currently, no oral medications are available for type 1 diabetes (T1D). While our recent
randomized placebo-controlled T1D trial revealed that oral verapamil had short-term …

Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic
β-cells but not neighbouring α-cells, even though both β-cells and α-cells are dysfunctional …

Objectives Readily accessible human pancreatic beta cells that are functionally close to
primary adult beta cells are a crucial model to better understand human beta cell physiology …