Protein corona: a new approach for nanomedicine design

VH Nguyen, BJ Lee - International journal of nanomedicine, 2017 - Taylor & Francis
After administration of nanoparticle (NP) into biological fluids, an NP–protein complex is
formed, which represents the “true identity” of NP in our body. Hence, protein–NP interaction …

[HTML][HTML] Get out or die trying: Peptide-and protein-based endosomal escape of RNA therapeutics

A Klipp, M Burger, JC Leroux - Advanced Drug Delivery Reviews, 2023 - Elsevier
RNA therapeutics offer great potential to transform the biomedical landscape, encompassing
the treatment of hereditary conditions and the development of better vaccines. However, the …

Understanding the lipid and protein corona formation on different sized polymeric nanoparticles

T Lima, K Bernfur, M Vilanova, T Cedervall - Scientific reports, 2020 - nature.com
When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like
proteins and lipids onto their surface, forming a “corona”. This biocorona is a dynamic and …

The influence of nanoparticle shape on protein corona formation

R Madathiparambil Visalakshan, LE González García… - Small, 2020 - Wiley Online Library
Nanoparticles have become an important utility in many areas of medical treatment such as
targeted drug and treatment delivery as well as imaging and diagnostics. These advances …

Polymer-coated magnetite nanoparticles for protein immobilization

K Mylkie, P Nowak, P Rybczynski, M Ziegler-Borowska - Materials, 2021 - mdpi.com
Since their discovery, magnetic nanoparticles (MNPs) have become materials with great
potential, especially considering the applications of biomedical sciences. A series of works …

The impact of protein corona on the biological behavior of targeting nanomedicines

M Farshbaf, H Valizadeh, Y Panahi, Y Fatahi… - International Journal of …, 2022 - Elsevier
For successful translation of targeting nanomedicines from bench to bedside, it is vital to
address their most common drawbacks namely rapid clearance and off-target accumulation …

The interaction between nanoparticles-protein corona complex and cells and its toxic effect on cells

N Liu, M Tang, J Ding - Chemosphere, 2020 - Elsevier
Once nanoparticles (NPs) contact with the biological fluids, the proteins immediately adsorb
onto their surface, forming a layer called protein corona (PC), which bestows the biological …

Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles

K Partikel, R Korte, NC Stein, D Mulac… - European Journal of …, 2019 - Elsevier
Upon intravenous administration of nanoparticles (NP) into the bloodstream, proteins bind
rapidly on their surface resulting in a formation of a so-called 'Protein Corona'. These …

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

S Khan, M Sharifi, JP Gleghorn, MMN Babadaei… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (NPs) have been used in numerous applications as anticancer, antibacterial
and antioxidant agents. Artificial engineering of protein interactions with NPs in biological …

Protein corona formation on lipid nanoparticles negatively affects the NLRP3 inflammasome activation

M Debnath, J Forster III, A Ramesh… - Bioconjugate …, 2023 - ACS Publications
The interaction between lipid nanoparticles (LNPs) and serum proteins, giving rise to a
unique identification in the form of the protein corona, has been shown to be associated with …