Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation
BM Fischer, E Pavlisko, JA Voynow - International journal of chronic …, 2011 - Taylor & Francis
Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of
chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow …
chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow …
COPD in China: the burden and importance of proper management
X Fang, X Wang, C Bai - Chest, 2011 - Elsevier
Although, to our knowledge, there has been no exhaustive or credible review of the
evidence of the disease burden of COPD in China, COPD has become an increasing public …
evidence of the disease burden of COPD in China, COPD has become an increasing public …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci
There is considerable variability in the susceptibility of smokers to develop chronic
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome
The impact of cigarette smoking can persist for extended periods following smoking
cessation and may involve epigenetic reprogramming. Changes in DNA methylation …
cessation and may involve epigenetic reprogramming. Changes in DNA methylation …
A genome-wide association study of pulmonary function measures in the Framingham Heart Study
The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …