Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

Tumor cell invasion and resistance to therapy are the most intractable biological
characteristics of cancer and, therefore, the most challenging for current cancer research …

Glycogen synthase kinase (GSK) 3β is a multifunctional serine/threonine protein kinase with
more than 100 substrates and interacting molecules. GSK3β is normally active in cells and …

Glycogen synthase kinase 3 (GSK3) was initially isolated as a critical protein in energy
metabolism. However, subsequent studies indicate that GSK-3 is a multi-tasking kinase that …

Our most recent studies demonstrate that miR-137 is downregulated in human bladder
cancer (BC) tissues, while treatment of human BC cells with isorhapontigenin (ISO) elevates …

Hyperthermia is a promising approach for improving cancer treatment in combination with
chemotherapy, radiotherapy and/or immunotherapy; however, its molecular mechanisms …

The mechanical properties of cells are important in tissue homeostasis and enable cell
growth, division, migration and the epithelial-mesenchymal transition. Mechanical properties …

В последние годы проводятся интенсивные исследования в области синтеза
сигнальных молекул, выполняющих важную роль в регуляции метаболизма и развитии …

Изобретение относится к медицине, в частности к применению соединения 2-Гидрокси-
3-[5-(морфолин-4-илметил) пиридин-2-ил]-1Н-индол-5-карбонитрил в качестве …