Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
EA Berger, PM Murphy, JM Farber - Annual review of …, 1999 - annualreviews.org
▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …
RANTES: a versatile and controversial chemokine
V Appay, SL Rowland-Jones - Trends in immunology, 2001 - cell.com
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful
leukocyte activator, a feature potentially relevant in a range of inflammatory disorders …
leukocyte activator, a feature potentially relevant in a range of inflammatory disorders …
HIV latency is established directly and early in both resting and activated primary CD4 T cells
L Chavez, V Calvanese, E Verdin - PLoS pathogens, 2015 - journals.plos.org
Highly active antiretroviral therapy (HAART) suppresses human immunodeficiency virus
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …
(HIV) replication to undetectable levels but cannot fully eradicate the virus because a small …
HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse
C Jolly, K Kashefi, M Hollinshead… - The Journal of …, 2004 - rupress.org
Direct cell–cell transfer is an efficient mechanism of viral dissemination within an infected
host, and human immunodeficiency virus 1 (HIV-1) can exploit this mode of spread …
host, and human immunodeficiency virus 1 (HIV-1) can exploit this mode of spread …
Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how …
Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140
A Trkola, TJ Ketas, KA Nagashima, L Zhao… - Journal of …, 2001 - Am Soc Microbiol
ABSTRACT CCR5 serves as a requisite fusion coreceptor for clinically relevant strains of
human immunodeficiency virus type 1 (HIV-1) and provides a promising target for antiviral …
human immunodeficiency virus type 1 (HIV-1) and provides a promising target for antiviral …
Trafficking of the HIV coreceptor CXCR4: role of arrestins and identification of residues in the C-terminal tail that mediate receptor internalization
MJ Orsini, JL Parent, SJ Mundell, JL Benovic - Journal of Biological …, 1999 - ASBMB
The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for
entry of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization …
entry of T-cell tropic human immunodeficiency virus. CXCR4 undergoes tonic internalization …
Chemokines and their receptors in lymphocyte traffic and HIV infection
P Loetscher, B Moser, M Baggiolini - Advances in immunology, 1999 - Elsevier
Publisher Summary This chapter reviews two research areas that attract unprecedented
attention in a growing number of laboratories the functions of chemokines, their receptors in …
attention in a growing number of laboratories the functions of chemokines, their receptors in …
The unexpected pleiotropic activities of RANTES
JA Levy - The Journal of Immunology, 2009 - journals.aai.org
The field of chemokines represented by the β-chemokine RANTES began just 20 years ago
(1). Several of these small basic proteins were discovered about the same time and defined …
(1). Several of these small basic proteins were discovered about the same time and defined …
Viral hijacking of G-protein-coupled-receptor signalling networks
Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and
harness their activated intracellular signalling pathways. All of these approaches ultimately …
harness their activated intracellular signalling pathways. All of these approaches ultimately …