Arachidonic acid induces ARE/Nrf2-dependent heme oxygenase-1 transcription in rat brain astrocytes
CC Lin, CC Yang, YW Chen, LD Hsiao… - Molecular …, 2018 - Springer
Arachidonic acid (AA) is a major product of phospholipid hydrolysis catalyzed by
phospholipase A 2 during neurodegenerative diseases. AA exerts as a second messenger …
phospholipase A 2 during neurodegenerative diseases. AA exerts as a second messenger …
Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite
In intact U937 cells, peroxynitrite promotes the mitochondrial formation of superoxide via a
Ca2+-dependent mechanism involving inhibition of complex III. Superoxide then readily …
Ca2+-dependent mechanism involving inhibition of complex III. Superoxide then readily …
Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite
Antisense technology was successfully employed to selectively reduce the expression of Bcl-
2 in U937 cells, while leaving their redox status intact. These cells displayed enhanced …
2 in U937 cells, while leaving their redox status intact. These cells displayed enhanced …
Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by …
Monocytes/macrophages respond to peroxynitrite with the triggering of events leading to
prevention of an otherwise prompt lethal response. This survival signaling regulated by …
prevention of an otherwise prompt lethal response. This survival signaling regulated by …
Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise nontoxic levels of reactive oxygen …
Exposure of U937 cells to low micromolar levels of ascorbic acid or dehydroascorbic acid,
while resulting in identical ascorbic acid accumulation, is unexpectedly associated with …
while resulting in identical ascorbic acid accumulation, is unexpectedly associated with …
Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite
Otherwise nontoxic levels of peroxynitrite promote toxicity in U937 cells pre‐exposed to low
micromolar concentrations of l‐ascorbic acid (AA). This event was associated with the …
micromolar concentrations of l‐ascorbic acid (AA). This event was associated with the …
Arachidonic acid inhibits neuronal nitric oxide synthase elicited by proinflammatory stimuli and promotes astrocyte survival with both exogenous and endogenous …
Cytosolic phospholipase A2‐inhibited astrocytes respond to the cocktail lipopolysaccharide/
interferon‐γ with an immediate formation of peroxynitrite (ONOO–) and a delayed lethal …
interferon‐γ with an immediate formation of peroxynitrite (ONOO–) and a delayed lethal …
Peroxynitrite-induced mitochondrial translocation of PKCα causes U937 cell survival
Our previous work has shown that non-toxic concentrations of peroxynitrite nevertheless
commit U937 cells to mitochondrial permeability-transition (MPT)-dependent necrosis that is …
commit U937 cells to mitochondrial permeability-transition (MPT)-dependent necrosis that is …
5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite
I Tommasini, A Guidarelli, L Palomba… - Journal of leukocyte …, 2006 - academic.oup.com
Endogenous generation of arachidonic acid via selective activation of cytosolic
phospholipase A2 has been implicated in the mechanism of monocytes/macrophage …
phospholipase A2 has been implicated in the mechanism of monocytes/macrophage …
A downstream role for protein kinase Cα in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells
A Guidarelli, L Cerioni, I Tommasini, B Brüne… - Biochemical …, 2005 - Elsevier
Exposure to an otherwise non-toxic concentration of peroxynitrite (ONOO−) promotes toxicity
in U937 cells supplemented with pharmacological inhibitors of protein kinase C (PKC). This …
in U937 cells supplemented with pharmacological inhibitors of protein kinase C (PKC). This …