Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems

M Rezaee, RK Oskuee, H Nassirli… - Journal of Controlled …, 2016 - Elsevier
Efficient gene therapy is mainly dependent on the gene transfer capability of gene delivery
vectors. Non-viral vectors have become the research interest of many researchers because …

Imaging preclinical tumour models: improving translational power

M De Jong, J Essers, WM Van Weerden - Nature Reviews Cancer, 2014 - nature.com
Recent developments and improvements of multimodal imaging methods for use in animal
research have substantially strengthened the options of in vivo visualization of cancer …

[HTML][HTML] The role of the helper lipid on the DNA transfection efficiency of lipopolyplex formulations

Z Du, MM Munye, AD Tagalakis, MDI Manunta… - Scientific reports, 2014 - nature.com
Multifunctional, lipopolyplex formulations comprising a mixture of cationic liposomes and
cationic, receptor-targeting peptides have potential use in gene therapy applications …

Lipid nanoparticles for gene delivery

Y Zhao, L Huang - Advances in genetics, 2014 - Elsevier
Nonviral vectors which offer a safer and versatile alternative to viral vectors have been
developed to overcome problems caused by viral carriers. However, their transfection …

Gadolinium-based nanoscale MRI contrast agents for tumor imaging

Y Cao, L Xu, Y Kuang, D Xiong, R Pei - Journal of Materials Chemistry …, 2017 - pubs.rsc.org
Gadolinium-based nanoscale magnetic resonance imaging (MRI) contrast agents (CAs)
have gained significant momentum as a promising nanoplatform for detecting tumor tissue in …

The effect of Cryoprotectants and storage conditions on the transfection efficiency, stability, and safety of lipid‐based nanoparticles for mRNA and DNA delivery

KN Kafetzis, N Papalamprou, E McNulty… - Advanced …, 2023 - Wiley Online Library
Lipid‐based nanoparticles have recently shown great promise, establishing themselves as
the gold standard in delivering novel RNA therapeutics. However, research on the effects of …

Assembly strategy of liposome and polymer systems for siRNA delivery

H Song, SL Hart, Z Du - International journal of pharmaceutics, 2021 - Elsevier
In recent years, gene therapy has made tremendous progress in the development of disease
treatment. Among them, siRNA offers specificity of gene silencing, ease of synthesis, and …

Strategies and materials of" SMART" non-viral vectors: Overcoming the barriers for brain gene therapy

Y Li, L Liu, W Ji, H Peng, R Zhao, X Zhang - Nano Today, 2020 - Elsevier
Most brain diseases such as tumors and neurodegenerative diseases are devastating for
patients with high morbidity and mortality. Gene therapy is a promising strategy for the …

Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging

MH Kim, HY Son, GY Kim, K Park, YM Huh, S Haam - Biomaterials, 2016 - Elsevier
Abstract T 1/T 2 dual-mode magnetic resonance (MR) contrast agents (DMCAs) have gained
much attention because of their ability to improve accuracy by providing two pieces of …

Receptor-targeted liposome-peptide-siRNA nanoparticles represent an efficient delivery system for MRTF silencing in conjunctival fibrosis

C Yu-Wai-Man, AD Tagalakis, MD Manunta, SL Hart… - Scientific reports, 2016 - nature.com
There is increasing evidence that the Myocardin-related transcription factor/Serum response
factor (MRTF/SRF) pathway plays a key role in fibroblast activation and that knocking down …