A hypoxic microenvironment leads to cancer progression and increases the metastatic
potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and …

Background Altered gene methylation, regulated by DNA methyltransferases (DNMT) 1, 3a
and 3b, contributes to tumorigenesis. However, the role of DNMT in pancreatic ductal …

Abstract Thiopurines including 6-thioguanine (SG), 6-mercaptopurine, and azathioprine are
effective anticancer agents with remarkable success in clinical practice, especially in …

In colorectal cancer (CRC), upregulation of the CXC motif chemokine receptor 4 (CXCR4) is
correlated with metastasis and poor prognosis, highlighting the need to further elucidate …

Objective To better understand the contribution of dysregulated DNA methyltransferase 1
(DNMT1) expression to the progression and biology of clear cell renal cell carcinoma …

The development of cervical cancer requires genetic and epigenetic factors which result in
the persistence of a malignant phenotype. Cervical cancer exhibits also some unique …

Background: Mutations of the human K-Ras 4B (K-Ras) G protein are associated with a
significant proportion of all human cancers. Despite this fact, a comprehensive analysis of K …

UV radiation-induced systemic immune suppression is a major risk factor for skin cancer
induction. The migration of dermal mast cells from the skin to the draining lymph nodes has …

Integration of tissue-engineered bone grafts with the host bone is vital for the healing of
critical-size bone defects. An important aspect of this process is bone resorption, which must …

Abnormal genome hypermethylation participates in the tumorigenesis and development of
prostate cancer. Prostate cancer cells highly express DNA methyltransferase 3 (DMNT3) …