Background Breast cancer is the most prevalent cancer among women worldwide and the
fifth cause of death among all cancer patients. Breast cancer development is driven by …

Systemic and local chronic inflammation might enhance the risk of pancreatic ductal
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …

Pancreatic ductal adenocarcinoma (PDAC) is poorly responsive to therapies and
histologically contains a paucity of neoplastic cells embedded within a dense desmoplastic …

Here, we utilized spontaneous models of pancreatic and lung cancer to examine how
neoantigenicity shapes tumor immunity and progression. As expected, neoantigen …

Acute inflammation is a response to an alteration induced by a pathogen or a physical or
chemical insult, which functions to eliminate the source of the damage and restore …

Oncogenic KRas reprograms pancreatic ductal adenocarcinoma (PDAC) cells to states
which are highly resistant to apoptosis. Thus, a major preclinical goal is to identify effective …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality
by malignancy in women and represents a main problem for public health worldwide. Tumor …

Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its
ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to …

Pancreatic cancer is a very aggressive disease characterized by a marked desmoplasia with
a predominant Th2 (GATA-3+) over Th1 (T-bet+) lymphoid infiltrate. We found that the ratio …