Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory and reparative
properties. Through specific interactions with immune cells that participate in both innate …

Current immunosuppressive therapy has led to excellent short-term survival rates in organ
transplantation. However, long-term graft survival rates are suboptimal, and a vast number of …

The cellular basis of the specific unresponsiveness that develops in DA rats treated with
cyclosporine (CSA) for 10 d after grafting a PVG heart was examined using an adoptive …

The large potential redundancy and the variety of means of attack in the immune system
have recently been compared to those in the military (1). For both systems to work effectively …

While small bone defects heal spontaneously, large bone defects need surgical intervention
for bone transplantation. Autologous bone grafts are the best and safest strategy for bone …

BACKGROUND: T cell mediated acute rejection of transplanted organ continues to be a
noticeable problem in solid organ transplantation. We showed that Curcumin is a potent …

Traditionally, T cells were CD4+ helper or CD8+ cytotoxic T cells, and with antibodies, they
were the soldiers of immunity. Now, many functionally distinct subsets of activated CD4+ and …

DA rats grafted with major histocompatibility complex-incompatible PVG heart grafts and
treated with cyclosporine (CY) for 10 d do not reject their grafts, and develop a state of …

Corneal transplantation represents an interesting model to investigate the contribution of
direct vs indirect Ag recognition pathways to the alloresponse. Corneal allografts are …

The immune response to an allograft activates lymphocytes with the capacity to cause
rejection. Activation of CD4+ CD25+ Foxp3+ T regulatory cells (Treg) can down-regulate …