Coronary microvascular dysfunction (CMD) encompasses several pathogenetic
mechanisms involving coronary microcirculation and plays a major role in determining …

Aims This meta-analysis aims to quantify the association of reduced coronary flow with all-
cause mortality and major adverse cardiovascular events (MACE) across a broad range of …

In 2008, the Guidelines for diagnosis and treatment of patients with vasospastic angina
(coronary spastic angina) 1 were developed by the Japanese Circulation Society, and the …

The need for a quantitative and operator-independent assessment of coronary
microvascular function is increasingly recognized. We propose the theoretical framework of …

Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …

Background: Fractional flow reserve (FFR) has become an established tool for guiding
treatment, but its graded relationship to clinical outcomes as modulated by medical therapy …

Obstructive disease of the epicardial coronary arteries was recognized as the cause of
angina pectoris> 2 centuries ago, and sudden thrombotic occlusion of an epicardial …

The development of novel, non-invasive techniques and standardization of protocols to
assess microvascular dysfunction have elucidated the key role of microvascular changes in …

Myocardial infarction (MI) remains the most common cause of heart failure (HF) worldwide.
For almost 50 years HF has been recognised as a determinant of adverse prognosis after …

Objectives The aim of this study was to compare Doppler flow velocity and thermodilution-
derived indexes and to determine the optimal thermodilution-based diagnostic thresholds for …