High-altitude exposures and intestinal barrier dysfunction

ZJ McKenna, F Gorini Pereira… - American Journal …, 2022 - journals.physiology.org
Gastrointestinal complaints are often reported during ascents to high altitude (> 2,500 m),
though their etiology is not known. One potential explanation is injury to the intestinal barrier …

Managing prolific sows in tropical environments

P Tummaruk, F De Rensis… - Molecular Reproduction …, 2023 - Wiley Online Library
Litter size in modern sows has been dramatically improved in recent decades by genetic
selection for highly prolific sows. In a tropical environment, the average total number of pigs …

Developing New Cyclodextrin-based Nanosponges complexes to improve vitamin D absorption in an in vitro study

F Uberti, F Trotta, P Pagliaro, DM Bisericaru… - International Journal of …, 2023 - mdpi.com
Vitamin D plays an important role in numerous cellular functions due to the ability to bind the
Vitamin D receptor (VDR), which is present in different tissues. Several human diseases …

[HTML][HTML] Trends in 3D models of inflammatory bowel disease

B Ferreira, AS Barros, C Leite-Pereira, J Viegas… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions,
namely Crohn's disease and ulcerative colitis. Despite all advances in the management of …

A 3D in-vitro biomimicking Caco-2 intestinal permeability model-based assessment of physically modified telmisartan towards an alkalizer-free formulation …

SK Sah, K Alam, M Kumari, R Malootty, S Nath… - European Journal of …, 2024 - Elsevier
Efficient telmisartan delivery for hypertension management requires the incorporation of
meglumine and/or sodium hydroxide as an alkalizer in the formulation. Long-term use of …

Selenylated Imidazo [1,2-a]pyridine Induces Apoptosis and Oxidative Stress in 2D and 3D Models of Colon Cancer Cells

GB Gomes, CS Zubieta, JS Guilhermi, MC Toffoli-Kadri… - Pharmaceuticals, 2023 - mdpi.com
Colon cancer incidence rates are increasing annually, a scenario aggravated by genetic
and epigenetic alterations that promote drug resistance. Recent studies showed that novel …

Metabolomics reveals the effects of Lactiplantibacillus plantarum dy-1 fermentation on the lipid-lowering capacity of barley β-glucans in an in vitro model of gut-liver …

S Fan, Y Zhou, Y Zhao, M Daglia, J Zhang… - International Journal of …, 2023 - Elsevier
Bioactive polysaccharides known as the biological response modifiers, can directly interact
with intestinal epithelium cells (IEC) and regulate key metabolic processes such as lipid …

Exercise in hypobaric hypoxia increases markers of intestinal injury and symptoms of gastrointestinal distress

ZJ McKenna, ZJ Fennel, QN Berkemeier… - Experimental …, 2022 - Wiley Online Library
New Findings What is the central question of this study? What is the effect of hypobaric
hypoxia on markers of exercise‐induced intestinal injury and symptoms of gastrointestinal …

Phloretin suppresses intestinal inflammation and maintained epithelial tight junction integrity by modulating cytokines secretion in in vitro model of gut inflammation

S Kapoor, YS Padwad - Cellular Immunology, 2023 - Elsevier
Ulcerative colitis is a type of inflammatory bowel disease which in long run can lead to
colorectal cancer (CRC). Chronic inflammation can be a key factor for the occurrence of …

Elevated risk of adverse effects from foodborne contaminants and drugs in inflammatory bowel disease: a review

T Walraven, M Busch, J Wang, JM Donkers… - Archives of …, 2024 - Springer
The global burden of Inflammatory bowel disease (IBD) has been rising over the last
decades. IBD is an intestinal disorder with a complex and largely unknown etiology. The …