Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved
lncRNAs undergo conserved processing, localization, and function remains unexplored. We …

To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale
analysis of 276 samples, analysing exome sequence, DNA copy number, promoter …

We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial
activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator …

Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology.
From the earliest observation that Wnt overexpression could lead to malignant …

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic
development and tissue homeostasis. Notably, comprehensive genetic studies in …