Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …

The glomerular basement membrane (GBM) is the central, non-cellular layer of the
glomerular filtration barrier that is situated between the two cellular components …

Alport syndrome affects up to 60,000 people in the United States. The proposed
reclassification of thin basement membrane nephropathy and some cases of focal …

The glomerular basement membrane (GBM) is a specialized structure with a significant role
in maintaining the glomerular filtration barrier. This GBM is formed from the fusion of two …

The glomerular filtration barrier comprises a fenestrated capillary endothelium, glomerular
basement membrane and podocyte slit diaphragm. Over the past decade we have come to …

Background There are an established and growing number of Mendelian genetic causes for
chronic kidney disease (CKD) in adults, though estimates of prevalence have been …

Chronic kidney disease (CKD) is a major public health challenge, affecting as much as 8 to
18% of the world population. Identifying childhood risk factors for future CKD may help …

The hereditary type IV collagen disease Alport syndrome (AS) always leads to end-stage
renal failure. Yesterday, for the past 90 years, this course was described as 'inevitable' …

Background Alport syndrome (ATS) is a progressive hereditary nephropathy characterized
by hematuria and proteinuria. It can be associated with extrarenal manifestations. In …