Update in interstitial lung disease 2020

AJ Podolanczuk, AW Wong, S Saito… - American Journal of …, 2021 - atsjournals.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–
induced coronavirus disease (COVID-19) dominated the year 2020. Initial reports of the long …

Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease

L Hou, X Xiong, Y Park, C Boix, B James, N Sun, L He… - Nature Genetics, 2023 - nature.com
Genetic variants associated with complex traits are primarily noncoding, and their effects on
gene-regulatory activity remain largely uncharacterized. To address this, we profile …

Organ specificity and heterogeneity of cancer-associated fibroblasts in colorectal cancer

N Miyashita, A Saito - International Journal of Molecular Sciences, 2021 - mdpi.com
Fibroblasts constitute a ubiquitous mesenchymal cell type and produce the extracellular
matrix (ECM) of connective tissue, thereby providing the structural basis of various organs …

Identification of genetic biomarkers, drug targets and agents for respiratory diseases utilising integrated bioinformatics approaches

FF Ahmed, AD Das, MJ Sumi, MZ Islam, MS Rahman… - Scientific Reports, 2023 - nature.com
Respiratory diseases (RD) are significant public health burdens and malignant diseases
worldwide. However, the RD-related biological information and interconnection still need to …

A novel therapeutic target for small-cell lung cancer: tumor-associated repair-like Schwann cells

S Cao, Y Wang, Y Zhou, Y Zhang, X Ling, L Zhang, J Li… - Cancers, 2022 - mdpi.com
Simple Summary Schwann cells (SCs) have been reported to support tumor spreading and
metastasis formation in both the in vitro and in vivo models. However, the role of SCs in the …

Reliable Identification and Interpretation of Single‐Cell Molecular Heterogeneity and Transcriptional Regulation using Dynamic Ensemble Pruning

Y Fan, Y Wang, F Wang, L Huang, Y Yang… - Advanced …, 2023 - Wiley Online Library
Unsupervised clustering is an essential step in identifying cell types from single‐cell RNA
sequencing (scRNA‐seq) data. However, a common issue with unsupervised clustering …

TGF-β-mediated epithelial–mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung …

N Miyashita, T Enokido, M Horie, K Fukuda… - Scientific Reports, 2021 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells
acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features …

[HTML][HTML] Bioinformatics and system biology approaches to identify molecular pathogenesis of polycystic ovarian syndrome, type 2 diabetes, obesity, and …

MA Hossain, M Al Amin, MI Hasan, M Sohel… - Informatics in Medicine …, 2022 - Elsevier
Female infertility may be caused by several medical conditions and environmental factors
that induce fallopian tube damage or hormonal difficulties. Several metabolic comorbidities …

Transcription factor roles in the local adaptation to temperature in the Andean Spiny Toad Rhinella spinulosa

F Hinostroza, I Araya-Duran, A Piñeiro, I Lobos… - Scientific Reports, 2024 - nature.com
Environmental temperature strongly influences the adaptation dynamics of amphibians,
whose limited regulation capabilities render them susceptible to thermal oscillations. A …

Identifying the Interaction Between Tuberculosis and SARS-CoV-2 Infections via Bioinformatics Analysis and Machine Learning

ZM Huang, JQ Kang, PZ Chen, LF Deng, JX Li… - Biochemical …, 2024 - Springer
The number of patients with COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 is still increasing. In the case of COVID-19 and tuberculosis (TB), the presence …