Many cell interactions depend on the assembly of cell protrusions; these include cell
attachment and migration in the extracellular matrix, cell–cell communication, and the ability …

The fascins are a structurally unique and evolutionarily conserved group of actin cross‐
linking proteins. Fascins function in the organisation of two major forms of actin‐based …

Exosomes are small membrane vesicles secreted into the extracellular compartment by
exocytosis. Tumor exosomes may be involved in the sampling of antigens to antigen …

Hodgkin's lymphoma is characterized by the combination of Reed-Sternberg (RS) cells and
a prominent inflammatory cell infiltrate. One of the intriguing questions regarding this …

Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …

Fascins are actin‐binding proteins that cross‐link filamentous actin into tightly packed
parallel bundles. These bundles are important for the organization and morphology of an …

Background Fascin-1 is an actin-bundling protein expressed in many human carcinomas,
although absent from most normal epithelia. Fascin-1 promotes filopodia formation …

Hodgkin lymphoma (HL) is a malignancy of unknown pathogenesis. The malignant Hodgkin
and Reed/Sternberg (HRS) cells derive from germinal center B cells (or rarely, T cells) but …

Fascin is an actin-bundling protein that is found in membrane ruffles, microspikes, and stress
fibers. The expression of fascin is greatly increased in many transformed cells, as well as in …

Background Hodgkin's disease and non-Hodgkin's B-cell lymphoma occasionally occur in
the same patient. The identification of a common precursor of the two types of lymphoma …