RNAi-based therapeutics and tumor targeted delivery in cancer

G Kara, GA Calin, B Ozpolat - Advanced drug delivery reviews, 2022 - Elsevier
Over the past decade, non-coding RNA-based therapeutics have proven as a great potential
for the development of targeted therapies for cancer and other diseases. The discovery of …

Aptamer-based targeted delivery of functional nucleic acids

S Xie, W Sun, T Fu, X Liu, P Chen, L Qiu… - Journal of the …, 2023 - ACS Publications
Functional nucleic acid (NA)-based drugs have a broad range of applications since they
allow the alteration and control of gene/protein expression patterns in cells. In principle …

Temperature-sensitive lipid-coated carbon nanotubes for synergistic photothermal therapy and gene therapy

Y Zhao, T Zhao, Y Cao, J Sun, Q Zhou, H Chen… - ACS …, 2021 - ACS Publications
The combination of photothermal therapy (PTT) and gene therapy (GT) shows great
potential to achieve synergistic anti-tumor activity. However, the lack of a controlled release …

[HTML][HTML] Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Breast cancer: conventional diagnosis and treatment modalities and recent patents and technologies

MI Nounou, F ElAmrawy, N Ahmed… - Breast cancer: basic …, 2015 - journals.sagepub.com
Breast cancer is the most prevalent cancer among women worldwide. However, increased
survival is due to the dramatic advances in the screening methods, early diagnosis, and …

[HTML][HTML] Nano-based delivery of RNAi in cancer therapy

Y Xin, M Huang, WW Guo, Q Huang, L Zhang, G Jiang - Molecular cancer, 2017 - Springer
Background RNA interference (RNAi), a newly developed method in which RNA molecules
inhibit gene expression, has recently received considerable research attention. In the …

Cyclodextrin based natural nanostructured carbohydrate polymers as effective non-viral siRNA delivery systems for cancer gene therapy

H Mousazadeh, Y Pilehvar-Soltanahmadi… - Journal of controlled …, 2021 - Elsevier
Short interfering RNAs (siRNAs), as small non-coding RNA fragments, are one of the widely
studied RNAi inducers for gene modulations. The reasonably designed siRNA probes …

Carbon nanotubes as an emerging nanocarrier for the delivery of doxorubicin for improved chemotherapy

R Chadar, O Afzal, SM Alqahtani… - Colloids and surfaces B …, 2021 - Elsevier
Carbon nanotubes (CNTs), a versatile nanocarrier for doxorubicin (DOX) delivery had
attracted significant attention in drug delivery of pharmaceuticals. Several properties such as …

Carbon nanotubes as cancer therapeutic carriers and mediators

KH Son, JH Hong, JW Lee - International journal of nanomedicine, 2016 - Taylor & Francis
Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because
of their unique structures and properties, including high aspect ratios, large surface areas …

[HTML][HTML] Aptamer grafted nanoparticle as targeted therapeutic tool for the treatment of breast cancer

A Sheikh, S Md, P Kesharwani - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Breast carcinomas repeat their number and grow exponentially making it extremely frequent
malignancy among women. Approximately, 70–80% of early diagnosed or non-metastatic …