Pre-transplant donor CD4− invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease
MT Rubio, M Bouillié, N Bouazza, T Coman… - Leukemia, 2017 - nature.com
Clinically useful pre-transplant predictive factors of acute graft-versus-host-disease (aGVHD)
after allogeneic hematopoietic stem cell transplantation (allo-SCT) are lacking. We …
after allogeneic hematopoietic stem cell transplantation (allo-SCT) are lacking. We …
CD8+CD44hi but not CD4+CD44hi memory T cells mediate potent graft antilymphoma activity without GVHD
S Dutt, J Baker, HE Kohrt, N Kambham… - Blood, The Journal …, 2011 - ashpublications.org
Allogeneic hematopoietic cell transplantation can be curative in patients with leukemia and
lymphoma. However, progressive growth of malignant cells, relapse after transplantation …
lymphoma. However, progressive growth of malignant cells, relapse after transplantation …
Infusion of donor-derived CD8+ memory T cells for relapse following allogeneic hematopoietic cell transplantation
L Muffly, K Sheehan, R Armstrong, K Jensen… - Blood …, 2018 - ashpublications.org
Murine models showed that CD8+ CD44hi memory T (TM) cells could eradicate malignant
cells without inducing graft-versus-host disease (GVHD). We evaluated the feasibility and …
cells without inducing graft-versus-host disease (GVHD). We evaluated the feasibility and …
In vitro polyclonal activation of conventional T cells with a CD28 superagonist protects mice from acute graft versus host disease
N Beyersdorf, S Werner, N Wolf… - European Journal of …, 2015 - Wiley Online Library
Upon transplantation of T cells from a CD28 superagonist (CD28‐SA) treated donor into an
irradiated allogeneic host, the CD28‐SA‐induced activation and expansion of Treg cells …
irradiated allogeneic host, the CD28‐SA‐induced activation and expansion of Treg cells …
During acute graft versus host disease CD28 deletion in donor CD8+, but not CD4+, T cells maintain antileukemia responses in mice
A Uri, F Lühder, T Kerkau… - European Journal of …, 2018 - Wiley Online Library
Donor lymphocyte infusions together with allogeneic hematopoietic stem cell transplantation
are routinely used as second‐line treatment for hematological malignancies. Mature T cells …
are routinely used as second‐line treatment for hematological malignancies. Mature T cells …
Hsp90 inhibition ameliorates CD4+ T cell‐mediated acute Graft versus Host disease in mice
C Berges, T Kerkau, S Werner, N Wolf… - Immunity …, 2016 - Wiley Online Library
Introduction For many patients with leukemia only allogeneic bone marrow transplantion
provides a chance of cure. Co‐transplanted mature donor T cells mediate the desired Graft …
provides a chance of cure. Co‐transplanted mature donor T cells mediate the desired Graft …