Sociology, genetics, and the coming of age of sociogenomics
Recent years have seen the birth of sociogenomics via the infusion of molecular genetic
data. We chronicle the history of genetics, focusing particularly on post-2005 genome-wide …
data. We chronicle the history of genetics, focusing particularly on post-2005 genome-wide …
Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring
Substantial shifts in reproductive behaviors have recently taken place in many high-income
countries including earlier age at menarche, advanced age at childbearing, rising …
countries including earlier age at menarche, advanced age at childbearing, rising …
The association between genetically elevated polyunsaturated fatty acids and risk of cancer
Background The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-
specific cancers remains uncertain. Methods Using a Mendelian randomization (MR) …
specific cancers remains uncertain. Methods Using a Mendelian randomization (MR) …
Genetic determinants of micronucleus formation in vivo
DJ Adams, B Barlas, RE McIntyre, I Salguero… - Nature, 2024 - nature.com
Genomic instability arising from defective responses to DNA damage or mitotic
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …
chromosomal imbalances can lead to the sequestration of DNA in aberrant extranuclear …
Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women
The percentage of people without children over their lifetime is approximately 25% in men
and 20% in women. Individual diseases have been linked to childlessness, mostly in …
and 20% in women. Individual diseases have been linked to childlessness, mostly in …
The relationships between women's reproductive factors: a Mendelian randomisation analysis
Background Women's reproductive factors include their age at menarche and menopause,
the age at which they start and stop having children and the number of children they have …
the age at which they start and stop having children and the number of children they have …
The impact of reproductive factors on the metabolic profile of females from menarche to menopause
GL Clayton, MC Borges, DA Lawlor - Nature Communications, 2024 - nature.com
We explore the relation between age at menarche, parity and age at natural menopause
with 249 metabolic traits in over 65,000 UK Biobank women using multivariable regression …
with 249 metabolic traits in over 65,000 UK Biobank women using multivariable regression …
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
Estimation of direct and indirect (ie parental and/or sibling) genetic effects on phenotypes is
becoming increasingly important. We compare several multivariate methods that utilize …
becoming increasingly important. We compare several multivariate methods that utilize …
An ancient ecospecies of Helicobacter pylori
E Tourrette, RC Torres, SL Svensson, T Matsumoto… - Nature, 2024 - nature.com
Helicobacter pylori disturbs the stomach lining during long-term colonization of its human
host, with sequelae including ulcers and gastric cancer,. Numerous H. pylori virulence …
host, with sequelae including ulcers and gastric cancer,. Numerous H. pylori virulence …
tstrait: a quantitative trait simulator for ancestral recombination graphs
D Tagami, G Bisschop, J Kelleher - Bioinformatics, 2024 - academic.oup.com
Ancestral recombination graphs (ARGs) encode the ensemble of correlated genealogical
trees arising from recombination in a compact and efficient structure, and are of fundamental …
trees arising from recombination in a compact and efficient structure, and are of fundamental …