Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health
C Morisseau, BD Hammock - Annual review of pharmacology …, 2013 - annualreviews.org
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …
Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases
WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
Soluble epoxide hydrolase: a potential target for metabolic diseases: 可溶性表氧化物酶: 代谢性疾病的潜在治疗靶点
摘要环氧‐二十碳三烯酸(Epoxyeicosatrienoic acids, EET) 是花生四烯酸的重要代谢产物. EET
在包括动脉粥样硬化, 高血压, 心脏纤维化, 糖尿病, 非酒精性脂肪肝以及肾脏疾病在内的诸多 …
在包括动脉粥样硬化, 高血压, 心脏纤维化, 糖尿病, 非酒精性脂肪肝以及肾脏疾病在内的诸多 …
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
JD Imig, BD Hammock - Nature reviews Drug discovery, 2009 - nature.com
The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …
Epoxides and soluble epoxide hydrolase in cardiovascular physiology
JD Imig - Physiological reviews, 2012 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …
Arachidonic acid cytochrome P450 epoxygenase pathway
AA Spector - Journal of lipid research, 2009 - ASBMB
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four
epoxyeicosatrienoic acid (EET) regioisomers, 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET, that …
epoxyeicosatrienoic acid (EET) regioisomers, 5, 6-, 8, 9-, 11, 12-, and 14, 15-EET, that …
Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products
CP Sun, XY Zhang, C Morisseau… - Journal of medicinal …, 2020 - ACS Publications
Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …
Inflammatory lipid mediators in adipocyte function and obesity
Survival of multicellular organisms depends on their ability to fight infection, metabolize
nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory …
nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory …
Soluble epoxide hydrolase: gene structure, expression and deletion
TR Harris, BD Hammock - Gene, 2013 - Elsevier
Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …
Epoxyeicosatrienoic acids and endothelium-dependent responses
WB Campbell, I Fleming - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that
are produced by the vascular endothelium in response to agonists such as bradykinin and …
are produced by the vascular endothelium in response to agonists such as bradykinin and …