Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

In contrast to the classical design of a probe with one binding site to target one specific
analyte, probes with multiple interaction sites or, alternatively, with single sites promoting …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive
response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor …

Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct
binding of metalloprotein heme centers, 2) serving as a potent antioxidant through reactive …

Hydrogen sulfide is a gaseous signaling molecule or gasotransmitter which plays important
roles in a wide spectrum of physiologic processes in the brain and peripheral tissues. Unlike …

Thyroid function is central in the control of physiological and pathophysiological processes.
Studies in animal models and human research have determined that thyroid hormones …

Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles
published more recently showed the beneficial biochemical properties of its endogenous …

The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …

FGF19 and FGF21 analogues are currently in clinical development for the potential
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …