The molecular composition of the cell wall is critical for the biology and ecology of each
fungal species. Fungal walls are composed of matrix components that are embedded and …

Candida albicans is a major fungal pathogen of humans, causing approximately 400,000 life-
threatening systemic infections world-wide each year in severely immunocompromised …

Fungi are primitive eukaryotes and have adapted to a variety of niches during evolution.
Some fungal species may interact with other life forms (plants, insects, mammals), but are …

Due to the high incidence of nosocomial Candida albicans infection, the first-line drugs for
C. albicans infection have been heavily used, and the emergence of drug-resistant strains …

The echinocandins are the newest class of antifungal agents in the clinical armory. These
secondary metabolites are non-competitive inhibitors of the synthesis of β-(1, 3)-glucan, a …

Cell-substrate adherence is a fundamental property of microorganisms that enables them to
exist in biofilms. Our study focuses on adherence of the fungal pathogen Candida albicans …

Candida species are part of the normal flora of humans, but once the immune system of the
host is impaired and they escape from commensal niches, they shift from commensal to …

Protein kinases play key roles in signaling and response to changes in the external
environment. The ability of Candida albicans to quickly sense and respond to changes in its …

Invasive fungal infections cause significant morbidity and mortality in part due to a limited
antifungal drug arsenal. One therapeutic challenge faced by clinicians is the significant host …

The cell wall of Candida albicans consists of an internal skeletal layer and an external
protein coat. This coat has a mosaic-like nature, containing c. 20 different protein species …